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Abstract Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity.
Due to an increasing demand for chemical diversity in screening programs, seeking therapeutic drugs from natural products, interest particularly in edible plants has grown throughout the world.
Botanicals and herbal preparations for medicinal usage contain various types of bioactive compounds. The focus of this paper is on the analytical methodologies, which include the extraction, isolation and characterization of active ingredients in botanicals and herbal preparations.
The common problems and key challenges in the extraction, isolation and characterization of active ingredients in botanicals and herbal preparations are discussed.
As extraction is the most important step in the analysis of constituents present in botanicals and herbal preparations, the strengths and weaknesses of different extraction techniques are discussed.
The analysis of bioactive compounds present in the plant extracts involving the applications of common phytochemical screening assays, chromatographic techniques such as HPLC and, TLC as well as non-chromatographic techniques such as immunoassay and Fourier Transform Infra Red FTIR are discussed.
Bioactive compound, Plant Extraction, Isolation, Herbal preparations, Natural products Introduction Natural products, such as plants extract, either as pure compounds or as standardized extracts, provide unlimited opportunities for new drug discoveries because of the unmatched availability of chemical diversity Cos et al.
The use of herbal medicines in Asia represents a long history of human interactions with the environment.
Plants used for traditional medicine contain a wide range of substances that can be used to treat chronic as well as infectious diseases Duraipandiyan et al. Due to the development of adverse effects and microbial resistance to the chemically synthesized drugs, men turned to ethnopharmacognosy.
They found literally thousands of phytochemicals from plants as safe and broadly effective alternatives with less adverse effect. Many beneficial biological activity such as anticancer, antimicrobial, antioxidant, antidiarrheal, analgesic and wound healing activity were reported.
In many cases the people claim the good benefit of certain natural or herbal products. However, clinical trials are necessary to demonstrate the effectiveness of a bioactive compound to verify this traditional claim. Clinical trials directed towards understanding the pharmacokinetics, bioavailability, efficacy, safety and drug interactions of newly developed bioactive compounds and their formulations extracts require a careful evaluation.
Clinical trials are carefully planned to safeguard the health of the participants as well as answer specific research questions by evaluating for both immediate and long-term side effects and their outcomes are measured before the drug is widely applied to patients.
According to the World Health Organization WHOnearly 20, medicinal plants exist in 91 countries including 12 mega biodiversity countries. The premier steps to utilize the biologically active compound from plant resources are extraction, pharmacological screening, isolation and characterization of bioactive compound, toxicological evaluation and clinical evaluation.
A brief summary of the general approaches in extraction, isolation and characterization of bioactive compound from plants extract can be found in Figure 1.Automatic works cited and bibliography formatting for MLA, APA and Chicago/Turabian citation styles.
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Universidade de Lisboa Faculdade de Ciências Departamento de Biologia Vegetal Screening and isolation of compounds with antimicrobial activity produced by. At least one author of an abstract must be registered for the Congress in order to be included in the abstract book. One author can present only ONE abstract.
STRUCTURE ELUCIDATION OF BIOACTIVE COMPOUNDS ISOLATED FROM ENDOPHYTES OF ALSTONIA SCHOLARIS AND ACMENA GRAVEOLENS by Nicholas J. Hundley A thesis .
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